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Articles

Vol. 1 No. 2 (2023): Volume 1, Issue 2, December 2023

Mifepristone for Induction of Labour at Term

  • Sumant R Shah
  • Vyapti K Pujara
Submitted
December 7, 2023
Published
2023-12-26

Abstract

Objective: To find out the Effect of Mifepristone for Induction of labour and to find its effect on Priming of Cervix.

Methodology:  Prospective study has been carried out in Tertiary care medical centre in periphery of metropolitan area, for a period of 2 months: 1st July 2023 to 26th August 2023. Consent of Ethical committee of the hospital and Written consent of the Patient was taken. An attempt is made to use Tab Mifepristone(200mg) alone or in combination with Tab mifepristone(200mg) followed by Low dose Tab Misoprostol is carried out in our Unit. We are restricting in this study, by Use of Mifepristone only for Induction of Labour.

Results:
8 (Eight) patients with age group of 20 to 28 years and majority of patients with 37 to 41 weeks (only one patient was postdate) were induced with T Mifepristone 200mg, where 5 patients came in Pre Latent phase and 3 Patients came in Latent Phase of Labour. Out of 8 patients, 7 patients delivered normally and 1 Patient had to undergo LSCS due to Fetal distress.

Induction delivery Interval varied from 7.5hrs to 17Hours. 5 Patients Delivered within 10 hours. 2 patients delivered within 10 to 17 hours. Mean Induction-Delivery interval was 8.81 hours. Out of 8 Patients only 1 patient had oligohydramnios. All Patients Baby Birth weight was varying from 2.3 to 3.3 kg with a mean of 2.59 kg. All patients have Apgar Score of >7 at 1 min and 10 at 5 min. No Postnatal complications were encountered.

Conclusion: Normally we find a study of Mifepristone followed by Misoprostol for Induction of Labour particularly for medical abortion. Very few studies have been carried out using Mifepristone alone for Ripening of cervix and Induction of labour. In a small number of patients this study has given very promising results without operative interference but may need interference by LSCS. Rising LSCS rate is a problem particularly in developing countries like India. Further study may help in finding out solution to decreasing LSCS rate.